When opening Medisoft an error states that the system can't find the gdiplus.dll
Add C:\Program Files\Common Files\Crystal Decisions\2.5\bin to the Windows Path variable.
Medisoft v15 doesn't use Crystal reports for the main reports. Medisoft v15 and the hotfix must still have a reference. Take an install cd for Version 11, 12 or 14, in the client\Crystal Reports folder run the CrystalSupport setup.